Endocrine Abstracts

Background: Adiponectin is an adipocyte-derived adipokine, down-regulated in obesity linked disorders. Here, we investigated the genotypic variability of adiponectin (at position; +T45G and +G276T) and its association with circulating adiponectin and metabolic syndrome in North Indian adult women.Methods: We compared metabolic syndrome (MetS; 269) women to without metabolic syndrome (wMetS; 272) women of North India. Genotype frequencies of the adiponect...

Background: The central component of the complement system, C3, is associated with obesity, type 2 diabetes and cardiovascular disease however the underlying reasons are unknown. In the present study we evaluated gene expression of C3, the cleavage product C3a and its cognate receptor C3aR in subcutaneous and omental adipose tissue in women.Methods: Women (n=140, 21–69 years, BMI 19.5–79 kg/m2) were evaluated for anthropomet...

Objective: Acylation Simulating Protein (ASP) has been shown to regulate lipid clearance and glucose uptake in adipose tissue. In vitro studies demonstrate that insulin stimulates ASP secretion from adipocytes. Individuals with obesity and/or metabolic disturbances (insulin resistance and type 2 diabetes) have increased plasma ASP, suggesting ASP resistance. Therefore, the present study evaluates whether ASP levels are influenced by the metabolic profile of overweight and obes...